Medical Informatics (MI) as an area of the science is relatively new, expanding its application domains, gaining more attention on its practical capability from people in the health field, and thus raising the issue of establishing a proper educational setting in schools. To provide some guiding information for those who intend or plan to have an educational body in their school, this paper attempts to explore a general framework where MI roots and the contents that MI deals with, while referencing historical backgrounds and establishments related to MI education in other countries. Having in mind those exploration, it tries to devise several organizational alternatives for MI education with consideration of Korea's given reality of school environments. for each alternative, some pros and cons are discussed, but no choice or preference to any of those alternatives is suggested, because the author believes the reality keeps varying and changing in our society.